Stressmarq公司生產研發的Alpha Synuclein 蛋白是一款比較熱銷的產品，該產品貨號為SPR-316。下文是對該產品的具體介紹，如需購買該產品，請聯系一級代理商欣博盛生物。
產品名稱：Alpha Synuclein 蛋白
產品描述：活性重組人Alpha Synuclein 蛋白單體 (2型)
應用范圍：WB, SDS-PAGE, In vivo assay, In vitro assay
濃度：各批次不同，請詳見說明書
標記物：無標簽
性質：重組
來源物種：人
表達系統：大腸桿菌 (E. coli)
氨基酸序列：MDVFMKGLSK AKEGVVAAAE KTKQGVAEAA GKTKEGVLYV GSKTKEGVVH GVATVAEKTK EQVTNVGGAV VTGVTAVAQK TVEGAGSIAA ATGFVKKDQL GKNEEGAPQE GILEDMPVDP DNEAYEMPSE EGYQDYEPEA
純度：>95%
蛋白長度：全長蛋白
Full Biological Activity:硫磺素 T 曲線顯示當2型單體 (SPR-316) 被PFFs引起聚集時形成的 β-sheet 聚集要比1型單體 (SPR-321) 少.
儲存緩沖液：PBS pH 7.4
儲存溫度：-80oC
運輸溫度：干冰. 運輸: 該產品會與其他同訂單產品分開發貨.
純化方式：離子交換層析純化
Protein Size：分子量約為14.46kDa.
引用該產品：Human Recombinant Alpha Synuclein Protein (StressMarq Biosciences, Canada, Cat # SPR-316B)
分析證書：該蛋白已經通過SDS-PAGE檢測證明純度為95%.
其他相關信息：經 LAL assay檢測，內毒素低于1EU/μg .
別名：Alpha Synuclein Protein, AlphaSyn Protein, NACP Protein, Non A4 component of amyloid Protein, PARK1 Protein, PARK4 Protein, SNCA Protein, SYN Protein, Parkison disease familial 1 Protein
研究領域：神經纖維纏結&Tau, 突觸核蛋白, 神經生物學, 神經衰退疾病, 帕金森氏病, 阿爾茨海默病
細胞定位：細胞核, 細胞質, 膜
Accession Number ：NP_000336.1
GeneID：6622
Swiss Prot：P37840
科研背景：
Alpha-Synuclein (SNCA) is expressed predominantly in the brain, where it is concentrated in presynaptic nerve terminals (1). Alpha-synuclein is highly expressed in the mitochondria of the olfactory bulb, hippocampus, striatum and thalamus (2). Functionally, it has been shown to significantly interact with tubulin (3), and may serve as a potential microtubule-associated protein. It has also been found to be essential for normal development of the cognitive functions; inactivation may lead to impaired spatial learning and working memory (4). SNCA fibrillar aggregates represent the major non A-beta component of Alzheimers disease amyloid plaque, and a major component of Lewy body inclusions, and Parkinson’s disease. Parkinson's disease (PD) is a common neurodegenerative disorder characterized by the progressive accumulation in selected neurons of protein inclusions containing alpha-synuclein and ubiquitin (5, 6).
參考資料：
1. “Genetics Home Reference: SNCA”. US National Library of Medicine. (2013).
2. Zhang L., et al. (2008) Brain Res. 1244: 40-52.
3. Alim M.A., et al. (2002) J Biol Chem. 277(3): 2112-2117.
4. Kokhan V.S., Afanasyeva M.A., Van’kin G. (2012) Behav. Brain. Res. 231(1): 226-230.
5. Spillantini M.G., et al. (1997) Nature. 388(6645): 839-840.
6. Mezey E., et al. (1998) Nat Med. 4(7): 755-757.
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