甲狀腺球蛋白（TG）多抗

簡(jiǎn)介：
甲狀腺球蛋白 (thyrobolulin，TG)是由甲狀腺濾泡上皮細(xì)胞合成的一種大分子糖蛋白，是甲狀腺濾泡內(nèi)膠質(zhì)的主要成分，合成的甲狀腺激素以球蛋白形式儲(chǔ)存在濾泡腔中。 在正常情況下，只有極微量的TG進(jìn)入血液循環(huán)。

其它名稱：甲狀腺球蛋白,TG多抗，甲狀腺球蛋白TG抗體

貨號(hào)：grTG02A

種類：抗體

應(yīng)用：Standard

特異性：thyrobolulin

來(lái)源：Rabbit

存貯：-20℃

產(chǎn)品說(shuō)明

In humans, the thyroid hormones T3 and T4 are synthesized in the thyroid gland in a process that crucially involves the iodoglycoprotein thyroglobulin. The overall structure of thyroglobulin is conserved in all vertebrates. Upon thyroglobulin delivery from thyrocytes to the follicular lumen of the thyroid gland via the secretory pathway, multiple tyrosine residues can become iodinated to form mono-iodotyrosine (MIT) and/or di-iodotyrosine (DIT); however, selective tyrosine residues lead to preferential formation of T4 and T3 at distinct sites. T4 formation involves oxidative coupling between two DIT side chains, and de novo T3 formation involves coupling between an MIT donor and a DIT acceptor. Thyroid hormone synthesis is stimulated by TSH activating its receptor (TSHR), which upregulates the activity of many thyroid gene products involved in hormonogenesis. Additionally, TSH regulates post-translational changes in thyroglobulin that selectively enhance its capacity for T3 formation — this process is important in iodide deficiency and in Graves disease. 167 different mutations, many of which are newly discovered, are now known to exist in TG (encoding human thyroglobulin) that can lead to defective thyroid hormone synthesis, resulting in congenital hypothyroidism.