17-DMAG (CAS:30562-34-6)
產品名稱： 17-DMAG (CAS:30562-34-6)
英文名稱： 17-DMAG
產品編號： SIH-114A
產品價格： 0
產品產地： 加拿大
品牌商標： StressMarq
更新時間： null
使用范圍： null
StressMarq
- 聯系人 :
- 地址 : 加拿大
- 郵編 :
- 所在區域 : 其他
- 電話 : 138****6620; 點擊查看
- 傳真 : 點擊查看
- 郵箱 : hedyl@stressmarq.com
Structure of 17-DMAG
17-DMAG
is a water soluble & cell-permeable analog of Geldanamycin and
17-AAG (1). It binds to the APTase site of human Hsp90a with high
affinity, has cytotoxic activity against many cancer cell lines (2), and
acts as angiogenesis inhibitor (3). This Hsp90 inhibitor shows promise
in preclinical models. 17-DMAG has excellent bioavailability, is widely
distributed to tissues, and is quantitatively metabolized much less than
is 17-AAG.
1. Bull E.E., et al.(2004) Clin. Cancer Res. 10: 8077.
2. Gossett D.R. et al.(2005) Gynecol. Oncol. 96: 381.
3. Kaur G. et al.(2004) Clin. Cancer Res. 10: 4813.
?