北京索萊寶科技有限公司 ?張凈花 ?010-56371206 ? 13426459985
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中文名稱：血藍(lán)蛋白
英文名：Keyhole limpet hemocyanin
英文簡稱：KLH
中文別名：血藍(lán)素
來源：美洲鱟血淋巴（Limulus polyphemus?hemolymph）
貨號(hào)：K8160
規(guī)格：10mg /100mg
分子量：8000-9000kDa
CAS：9013-72-3
純度：Protein ≥85?% by biuret
應(yīng)用：生物活性測定、免疫學(xué)研究、封閉血藍(lán)蛋白抗體
研究背景：
KLH is used extensively as a carrier protein in the production of antibodies for research, biotechnology and therapeutic applications. Haptens are substances with a low molecular weight such as peptides, small proteins and drug molecules that are generally not immunogenic and require the aid of a carrier protein to stimulate a response from the immune system in the form of antibody production. KLH is the most widely employed carrier protein for this purpose. KLH is an effective carrier protein for several reasons. Its large size and numerous epitopes generate a substantial immune response, and abundance of lysine residues for coupling haptens allows a high hapten:carrier protein ratio, increasing the likelihood of generating hapten-specific antibodies. In addition, because KLH is derived from the limpet, a gastropod, it is phylogenetically distant from mammalian proteins, thus reducing false positives in immunologically-based research techniques in mammalian model organisms.KLH can also be a challenging molecule to work with because of its propensity to aggregate and precipitate. Aggregates remain immunogenic, but limit the ability to conjugate haptens, and are difficult to manipulate in the laboratory. A high-quality KLH preparation with clear opalescent blue color is the best indicator of KLH solubility.
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運(yùn)輸和儲(chǔ)存：4℃運(yùn)輸，-20℃儲(chǔ)存，避免反復(fù)凍融。
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